{"id":2006,"date":"2026-03-05T10:42:32","date_gmt":"2026-03-05T10:42:32","guid":{"rendered":"https:\/\/www.pk-pharmakommunikation.de\/blog\/weight-loss-fact-checked-the-not-so-small-difference\/"},"modified":"2026-07-27T07:19:32","modified_gmt":"2026-07-27T07:19:32","slug":"weight-loss-fact-checked-the-not-so-small-difference","status":"publish","type":"post","link":"https:\/\/www.pk-pharmakommunikation.de\/en\/blog\/weight-loss-fact-checked-the-not-so-small-difference\/","title":{"rendered":"Weight loss, fact-checked: the not-so-small difference"},"content":{"rendered":"<p data-start=\"98\" data-end=\"108\">Same diet.<\/p>\n<p data-start=\"110\" data-end=\"131\">Same training volume.<\/p>\n<p data-start=\"133\" data-end=\"151\">Different results:<\/p>\n<p data-start=\"155\" data-end=\"262\"><strong data-start=\"155\" data-end=\"161\">He<\/strong> loses four kilos. <strong data-start=\"180\" data-end=\"187\">She<\/strong> loses her patience. But what are the reasons for this \u201cgender weight gap\u201d?<\/p>\n<p data-start=\"264\" data-end=\"316\"><strong data-start=\"264\" data-end=\"316\">Muscle mass: The starting point is not identical<\/strong><\/p>\n<p data-start=\"318\" data-end=\"637\">On average, men have around 10\u201315% more fat-free mass than women of the same age. The share of skeletal muscle is about 40\u201345% of body weight in men, and more like 30\u201335% in women. More muscle mass, however, also means a higher basal metabolic rate: One kilogram of fat-free mass burns about 13\u201315 kcal per day at&nbsp;rest.<\/p>\n<ul>\n<li data-start=\"641\" data-end=\"745\">In practice, this often results in a daily energy expenditure that is about 100\u2013300 kcal higher for&nbsp;men.<\/li>\n<\/ul>\n<p data-start=\"747\" data-end=\"796\"><strong data-start=\"747\" data-end=\"796\">Energy regulation: Earlier counter-regulation<\/strong><\/p>\n<p data-start=\"798\" data-end=\"1084\">In women, hormonal regulation reacts more sensitively to energy deficits. The level of the satiety hormone leptin can drop by 30\u201350% even with moderate restriction, while the hunger hormone ghrelin increases. At the same time, adaptive thermogenesis reduces energy expenditure by 5\u201315%.<\/p>\n<ul>\n<li data-start=\"1088\" data-end=\"1163\">A woman\u2019s body therefore dampens expenditure earlier and more consistently.<\/li>\n<\/ul>\n<p data-start=\"1165\" data-end=\"1213\"><strong data-start=\"1165\" data-end=\"1213\">Cycle: Weight is not a fixed reference value<\/strong><\/p>\n<p data-start=\"1215\" data-end=\"1490\">Weight fluctuations of 1\u20132 kg within a cycle are physiological. In the luteal phase, basal metabolic rate increases by 2\u201310%, while at the same time, in many women spontaneous energy intake increases by 90\u2013500 kcal per day. Progesterone additionally promotes fluid retention.<\/p>\n<ul>\n<li data-start=\"1494\" data-end=\"1585\">Short-term scale values therefore often show the hormonal dynamics \u2014 not actual fat change.<\/li>\n<\/ul>\n<p data-start=\"1587\" data-end=\"1627\"><strong data-start=\"1587\" data-end=\"1627\">Menopause: When distribution changes<\/strong><\/p>\n<p data-start=\"1629\" data-end=\"1789\">With menopause, visceral fat volume increases by around 40\u201360%, while muscle mass decreases significantly \u2014 even if total body weight increases only moderately.<\/p>\n<ul>\n<li data-start=\"1793\" data-end=\"2038\">On the one hand, visceral fat is metabolically active and promotes insulin resistance, inflammatory processes and cardiovascular risk. On the other hand, with less muscle mass, resting energy expenditure can be around 100\u2013200 kcal per day&nbsp;lower.<\/li>\n<\/ul>\n<p data-start=\"2042\" data-end=\"2087\"><strong data-start=\"2042\" data-end=\"2087\">So what is especially important for&nbsp;women<\/strong><\/p>\n<ul>\n<li data-start=\"2089\" data-end=\"2232\">Strength training + sufficient protein: 2\u20133\u00d7\/week progressive training; 1.6\u20132.0 g protein\/kg BW, to secure muscle mass and basal metabolic rate<\/li>\n<li data-start=\"2234\" data-end=\"2300\">Moderate calorie deficit: about 300\u2013500 kcal instead of crash&nbsp;diet<\/li>\n<li data-start=\"2302\" data-end=\"2468\">Plan for cycle &amp; life stage: 1\u20132 kg cyclical fluctuations are physiological; postmenopausal, focus more on waist circumference, strength values and metabolic markers)<\/li>\n<\/ul>\n<p data-start=\"2472\" data-end=\"2564\">What do you think: Do weight-loss strategies sufficiently take sex differences into account?<\/p>\n<p data-start=\"2570\" data-end=\"2715\" data-is-last-node data-is-only-node><a href=\"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/740\" target=\"_blank\" rel=\"noopener\">Szeliga A et al. The Impact of the Menopausal Transition on Body Composition and Abdominal Fat Redistribution. J Clin Med. 2026 Jan 16;15(2):740.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Same diet. Same training volume. Different results: He loses four kilos. She loses her patience. But what are the reasons for this \u201cgender weight gap\u201d? Muscle mass: The starting point is not identical On average, men have around 10\u201315% more fat-free mass than women of the same age. The share of skeletal muscle is&nbsp;about&nbsp;[\u2026]<\/p>\n","protected":false},"author":4,"featured_media":2003,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","wp_typography_post_enhancements_disabled":false,"footnotes":""},"categories":[20],"tags":[],"class_list":["post-2006","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Weight loss, fact-checked: the not-so-small difference &#8226; PK Pharmakommunikation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pk-pharmakommunikation.de\/en\/blog\/weight-loss-fact-checked-the-not-so-small-difference\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Weight loss, fact-checked: the not-so-small difference &#8226; PK Pharmakommunikation\" \/>\n<meta property=\"og:description\" content=\"Same diet. Same training volume. Different results: He loses four kilos. She loses her patience. But what are the reasons for this \u201cgender weight gap\u201d? Muscle mass: The starting point is not identical On average, men have around 10\u201315% more fat-free mass than women of the same age. The share of skeletal muscle is about [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pk-pharmakommunikation.de\/en\/blog\/weight-loss-fact-checked-the-not-so-small-difference\/\" \/>\n<meta property=\"og:site_name\" content=\"PK Pharmakommunikation\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-05T10:42:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-27T07:19:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pk-pharmakommunikation.de\/wp-content\/uploads\/ChatGPT-Image-3.-Maerz-2026-10_25_16-e1772707119811.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Elke\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Elke\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/blog\\\/weight-loss-fact-checked-the-not-so-small-difference\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/blog\\\/weight-loss-fact-checked-the-not-so-small-difference\\\/\"},\"author\":{\"name\":\"Elke\",\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/#\\\/schema\\\/person\\\/c09686d559e7fc144b0cde96970f2313\"},\"headline\":\"Weight loss, fact-checked: the not-so-small difference\",\"datePublished\":\"2026-03-05T10:42:32+00:00\",\"dateModified\":\"2026-07-27T07:19:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/blog\\\/weight-loss-fact-checked-the-not-so-small-difference\\\/\"},\"wordCount\":377,\"publisher\":{\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/blog\\\/weight-loss-fact-checked-the-not-so-small-difference\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/wp-content\\\/uploads\\\/ChatGPT-Image-3.-Maerz-2026-10_25_16-e1772707119811.png\",\"articleSection\":[\"Blog\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/blog\\\/weight-loss-fact-checked-the-not-so-small-difference\\\/\",\"url\":\"https:\\\/\\\/www.pk-pharmakommunikation.de\\\/en\\\/blog\\\/weight-loss-fact-checked-the-not-so-small-difference\\\/\",\"name\":\"Weight loss, fact-checked: the not-so-small difference &#8226; 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